Molecular mechanisms of α-synuclein neurodegeneration
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چکیده
منابع مشابه
Molecular imaging insights into neurodegeneration: focus on α-synuclein radiotracers.
Neurodegenerative diseases characterized by the presence of α-synuclein-a hallmark of pathologic inclusions termed Lewy bodies-include Parkinson's disease, dementia with Lewy bodies, and multiple-system atrophy. Although motor symptoms are related to the altered presynaptic dopaminergic function in these diseases, the appearance of α-synuclein inclusions precedes the involvement of the nigrostr...
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Accumulation of misfolded alpha-synuclein (α-syn) into Lewy bodies (LBs) and Lewy neurites (LNs) is a major hallmark of Parkinson's disease (PD) and dementia with LBs (DLB). Recent studies showed that synthetic preformed fibrils (pffs) recruit endogenous α-syn and induce LB/LN pathology in vitro and in vivo, thereby implicating propagation and cell-to-cell transmission of pathological α-syn as ...
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Sreeganga Chandra,1 Gilbert Gallardo,1 Rafael Fernández-Chacón,2 Oliver M. Schlüter,3 and Thomas C. Südhof1,* 1Center for Basic Neuroscience Department of Molecular Genetics Howard Hughes Medical Institute University of Texas Southwestern Medical Center Dallas, Texas 75390 2Departmento Fisiología Médica y Biofísica Universidad de Sevilla Avenida Sánchez-Pizjuán 4 41009-Sevilla Spain 3MPI für Ex...
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OF DISSERTATION Radhika Anand Vaishnav The Graduate School University of Kentucky 2007 MOLECULAR MECHANISMS OF OLFACTORY NEURODEGENERATION _________________________________ ABSTRACT OF DISSERTATION _________________________________OF DISSERTATION _________________________________ A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Co...
متن کامل[The role of extracellular α-synuclein in molecular mechanisms of cell death].
Recently published data demonstrated that increased release, oligomerization and toxicity of α-synuclein (ASN) is a key molecular process in pathophysiology of neurodegenerative diseases classified as synucleinopathies (e.g. Parkinson disease or Alzheimer's disease). It was proved that the excessive release of ASN into the extracellular space, driven by environmental factors as well as neurodeg...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
سال: 2009
ISSN: 0925-4439
DOI: 10.1016/j.bbadis.2008.09.013